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Dr. Ansu Abu Alex

Dr. Ansu Abu Alex


PhD in Biological Sciences 

Christian Medical College, Vellore, India

MSc in Biomedical Genetics 

Vellore Institute of Technology, Vellore


Dr. Ansu Abu Alex is working as a Scientist in Rajagiri Hospital since September 2020. She has over 12 years of experience in clinical flow cytometry.

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She is experienced in leukemia and lymphoma diagnosis, MRD monitoring in leukemia, CD34 enumeration for bone marrow transplantation, immunodeficiencies and immune reconstitution studies, cell sorting, cell cycle and cytotoxicity assays, CliniMACS depletion protocols. Trained in operating BD FACS Calibur, BD FACS Canto II, BC Gallios and BC DxFLEX.

She has worked extensively on primary cell culture, adherent and non-adherent cell line maintenance, handling of mice strains like FVB/N (acute promyelocytic leukemia transplantable mouse model) and all mouse experiments, molecular biology techniques and KIR genotyping.

She has more 16 publications in International and National journals to her credit.

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  • Laboratory Head, Flowcytometry facility Shenoy’s CARE Private Limited, Kochi, India: 2018 - 2020
  • Lecturer, Flow cytometry facility in-charge, Department of Hematology, Christian Medical College, Vellore: 2009 - 2018 


  • Impact of arsenic trioxide on the immune and cellular response in acute   promyelocytic leukemia patients and in APL mouse model, funded by CEFIPRA.
  • The role of arsenic trioxide in modulating the immune responses in acute promyelocytic leukemia patients and in APL mouse model, funded by ICMR.       
  • Evaluation of efficacy of ex-vivo expanded and optimized natural killer cells as an   adjunct to allogeneic stem cell transplantation in the treatment of de novo acute   myeloid leukemia, India Alliance, DBT Wellcome, co-investigator.


  • Outstanding Post Graduate Research Award IJMPO – Indian Journal of Medical and Paediatric Oncology and Christian Medical College, Vellore, India
  • BEST ABSTRACT award at 7th International Hematologic malignancies Conference:      BTG 2016, held at Guangzou, China (oral presentation).
  • Dr. J .C Patel Best Paper Award at the 54th Annual Conference of Indian Society of Hematology and Blood Transfusion held in Mumbai in 2013 (oral presentation).
  • International Travel Support from CSIR (Council of Scientific and Industrial research) for the 6th International symposium on Acute Promyelocytic Leukemia held in Rome in 2013 (oral presentation).
  • ASH abstract achievement award, American Society of Hematology Annual Meeting at New Orleans.
  • ASH abstract achievement award, American Society of Hematology Annual Meeting at Atlanta
  • Merit scholarship from VIT University, Vellore for MSc. Biomedical Genetics.
  • Gold medal from Kerala University for First Rank in B.Sc (Biotechnology)


  • Alex AA, Ganesan S, Palani HK, Balasundaram N, David S, Lakshmi KM, Kulkarni UP, Nisham PN, Korula A, Devasia AJ, Janet NB, Abraham A, Srivastava A, George B, Padua RA, Chomienne C, Balasubramanian P, Mathews V. Arsenic Trioxide Enhances the NK Cell Cytotoxicity Against Acute Promyelocytic Leukemia While Simultaneously Inhibiting Its Bio-Genesis. Front Immunol. 2018 Jun 14;9:1357. doi: 10.3389/fimmu.2018.01357. PMID: 29963052; PMCID: PMC6010577.
  • Ganesan S, Alex AA, Chendamarai E, Balasundaram N, Palani HK, David S, Kulkarni U, Aiyaz M, Mugasimangalam R, Korula A, Abraham A, Srivastava A, Padua RA, Chomienne C, George B, Balasubramanian P, Mathews V. Rationale and efficacy of proteasome inhibitor combined with arsenic trioxide in the treatment of acute promyelocytic leukemia. Leukemia. 2016 Nov;30(11):2169-2178. doi: 10.1038/leu.2016.227. Epub 2016 Aug 18. PMID: 27560113; PMCID: PMC5097069
  • Patkar N, Alex AA, B B, Ahmed R, Abraham A, George B, Vishwabandya A, Srivastava A, Mathews V. Standardizing minimal residual disease by flow cytometry for precursor B lineage acute lymphoblastic leukemia in a developing country. Cytometry B Clin Cytom. 2012 Jul;82(4):252-8. doi: 10.1002/cyto.b.21017. Epub 2012 Mar 29. PMID: 22467604
  • Kulkarni U, Ganesan S, Alex AA, Palani H, David S, Balasundaram N, Venkatraman A, Thenmozhi M, Jeyaseelan L, Korula A, Devasia A, Abraham A, Janet NB, Balasubramanian P, George B, Mathews V. A phase II study evaluating the role of bortezomib in the management of relapsed acute promyelocytic leukemia treated upfront with arsenic trioxide. Cancer Med. 2020 Feb 14:10.1002/cam4.2883. doi: 10.1002/cam4.2883. Epub ahead of print. PMID: 32059085.
  • Patel S, Guerenne L, Gorombei P, Omidvar N, Schlageter MH, Alex AA, Ganesan S, West R, Adès L, Mathews V, Krief P, Pla M, Fenaux P, Chomienne C, Padua RA. pVAX14DNA-mediated add-on immunotherapy combined with arsenic trioxide and all-trans retinoic acid targeted therapy effectively increases the survival of acute promyelocytic leukemia mice. Blood Cancer J. 2015 Dec 11;5(12):e374. doi: 10.1038/bcj.2015.102. PMID: 26657197; PMCID: PMC4735069.
  • Chendamarai E, Ganesan S, Alex AA, Kamath V, Nair SC, Nellickal AJ, Janet NB, Srivastava V, Lakshmi KM, Viswabandya A, Abraham A, Aiyaz M, Mullapudi N, Mugasimangalam R, Padua RA, Chomienne C, Chandy M, Srivastava A, George B, Balasubramanian P, Mathews V. Comparison of newly diagnosed and relapsed patients with acute promyelocytic leukemia treated with arsenic trioxide: insight into mechanisms of resistance. PLoS One. 2015 Mar 30;10(3):e0121912. doi: 10.1371/journal.pone.0121912. PMID: 25822503; PMCID: PMC4378855.
  • Deshpande P, Kathirvel K, Alex AA, Korula A, George B, Shaji RV, Mathews V. Leukocyte Adhesion Deficiency-I: Clinical and Molecular Characterization in an Indian Population. Indian J Pediatr. 2016 Aug;83(8):799-804. doi: 10.1007/s12098-016-2051-0. Epub 2016 Feb 29. PMID: 26924654.
  • Senapati J, Devasia AJ, Alex AA, George B. Early T cell precursor lymphoid blast crisis of chronic myeloid leukemia - a novel transformation. Hematol Oncol Stem Cell Ther. 2015 Mar;8(1):43-6. doi: 10.1016/j.hemonc.2014.11.002. Epub 2014 Nov 26. PMID: 25497977.
  • Patkar N, Nair S, Alex AA, Parihar M, Manipadam MT, Arora N, Ahmed R, Abraham A, George B, Viswabandya A, Srivastava V, Srivastava A, Mathews V. Clinicopathological features of hepatosplenic T cell lymphoma: a single centre experience from India. Leuk Lymphoma. 2012 Apr;53(4):609-15. doi: 10.3109/10428194.2011.622421. Epub 2011 Dec 5. PMID: 21916832.
  • Ganesan S, Palani HK, Lakshmanan V, Balasundaram N, Alex AA, David S, Venkatraman A, Korula A, George B, Balasubramanian P, Palakodeti D, Vyas N, Mathews V. Stromal cells downregulate miR-23a-5p to activate protective autophagy in acute myeloid leukemia. Cell Death Dis. 2019 Sep 30;10(10):736. doi: 10.1038/s41419-019-1964-8. PMID: 31570693; PMCID: PMC6769009.
  • David S, Nair SC, Singh GS, Alex AA, Ganesan S, Palani HK, Balasundaram N, Lakshmi KM, Joshi A, Kannan S, Korula A, Nambiatheyil Aboobacker F, Abraham A, George B, Apte SJ, Srivastava A, Mathews V. Prevalence of FVIII inhibitors in severe haemophilia A patients: Effect of treatment and genetic factors in an Indian population. Haemophilia. 2019 Jan;25(1):67-74. doi: 10.1111/hae.13633. Epub 2018 Nov 14. PMID: 30427567.
  • Jain P, Korula A, Deshpande P, Pn N, Abu Alex A, Abraham A, Srivastava A, Janet NB, Lakshmi KM, Balasubramanian P, George B, Mathews V. Adult Acute Lymphoblastic Leukemia: Limitations of Intensification of Therapy in a Developing Country. J Glob Oncol. 2018 Sep;4:1-12. doi: 10.1200/JGO.17.00014. PMID: 30222028; PMCID: PMC6371642.
  • Philip C, George B, Ganapule A, Korula A, Jain P, Alex AA, Lakshmi KM, Sitaram U, Abubacker FN, Abraham A, Viswabandya A, Srivastava VM, Srivastava A, Balasubramanian P, Mathews V. Acute myeloid leukaemia: challenges and real world data from India. Br J Haematol. 2015 Jul;170(1):110-7. doi: 10.1111/bjh.13406. Epub 2015 Apr 9. PMID: 25858293; PMCID: PMC4864448.
  • Chendamarai E, Balasubramanian P, George B, Viswabandya A, Abraham A, Ahmed R, Alex AA, Ganesan S, Lakshmi KM, Sitaram U, Nair SC, Chandy M, Janet NB, Srivastava VM, Srivastava A, Mathews V. Role of minimal residual disease monitoring in acute promyelocytic leukemia treated with arsenic trioxide in frontline therapy. Blood. 2012 Apr 12;119(15):3413-9. doi: 10.1182/blood-2011-11-393264. Epub 2012 Feb 28. PMID: 22374701.
  • Le Pogam C, Patel S, Gorombei P, Guerenne L, Krief P, Omidvar N, Tekin N, Bernasconi E, Sicre F, Schlageter MH, Chopin M, Noguera ME, West R, Abu A, Mathews V, Pla M, Fenaux P, Chomienne C, Padua RA. DNA-mediated adjuvant immunotherapy extends survival in two different mouse models of myeloid malignancies. Oncotarget. 2015 Oct 20;6(32):32494-508. doi: 10.18632/oncotarget.5572. PMID: 26378812; PMCID: PMC4741708.
  • Parvathypriya Chandramohan, Avinash Jain, Glindow Antony, Nayaryanan   K Ansu Abu Alex, Padmanabha Shenoy . Low Dose Rituximab protocol in Rheumatoid Arthritis – Outcome and economic impact. Submitted to The Lancet Rheumatology 2020.


  • The International Society for Advancement of Cytometry (ISAC) 
  • The Cytometry Society - India (TCS)

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